Version 4 SHEET 1 1240 776 WIRE 240 -240 224 -240 WIRE 448 -240 432 -240 WIRE 240 -224 240 -240 WIRE 448 -224 448 -240 WIRE -752 -48 -768 -48 WIRE -560 -32 -576 -32 WIRE -464 -32 -480 -32 WIRE -432 -32 -464 -32 WIRE -320 -32 -320 -64 WIRE -320 -32 -352 -32 WIRE -16 -32 -16 -64 WIRE -16 -32 -160 -32 WIRE 176 -16 144 -16 WIRE 288 -16 288 -48 WIRE 288 -16 256 -16 WIRE 592 -16 592 -48 WIRE 592 -16 448 -16 WIRE 752 -16 720 -16 WIRE 864 -16 864 -48 WIRE 864 -16 832 -16 WIRE 1168 -16 1168 -48 WIRE 1168 -16 1024 -16 WIRE -752 0 -768 0 WIRE -160 64 -160 -32 WIRE -128 64 -160 64 WIRE -560 80 -592 80 WIRE -464 80 -464 -32 WIRE -464 80 -480 80 WIRE -432 80 -464 80 WIRE -16 80 -16 -32 WIRE -16 80 -64 80 WIRE 448 80 448 -16 WIRE 480 80 448 80 WIRE 1024 80 1024 -16 WIRE 1056 80 1024 80 WIRE -320 96 -320 -32 WIRE -320 96 -368 96 WIRE -304 96 -320 96 WIRE -192 96 -224 96 WIRE -128 96 -192 96 WIRE -16 96 -16 80 WIRE 48 96 -16 96 WIRE 144 96 144 -16 WIRE 144 96 128 96 WIRE 176 96 144 96 WIRE 592 96 592 -16 WIRE 592 96 544 96 WIRE 624 96 592 96 WIRE 720 96 720 -16 WIRE 720 96 704 96 WIRE 752 96 720 96 WIRE 1168 96 1168 -16 WIRE 1168 96 1120 96 WIRE -432 112 -480 112 WIRE 288 112 288 -16 WIRE 288 112 240 112 WIRE 304 112 288 112 WIRE 416 112 384 112 WIRE 480 112 416 112 WIRE 864 112 864 -16 WIRE 864 112 816 112 WIRE 880 112 864 112 WIRE 992 112 960 112 WIRE 1056 112 992 112 WIRE -192 128 -192 96 WIRE 176 128 128 128 WIRE 752 128 704 128 WIRE -480 144 -480 112 WIRE 416 144 416 112 WIRE 992 144 992 112 WIRE 128 160 128 128 WIRE 704 160 704 128 WIRE -192 192 -192 176 WIRE 416 208 416 192 WIRE 992 208 992 192 WIRE -592 272 -592 80 WIRE 1168 272 1168 96 WIRE 1168 272 -592 272 FLAG 240 -224 0 FLAG 448 -224 0 FLAG -400 64 V+ IOPIN -400 64 BiDir FLAG 144 -240 V+ IOPIN 144 -240 BiDir FLAG -400 128 V- IOPIN -400 128 BiDir FLAG 352 -240 V- IOPIN 352 -240 BiDir FLAG -192 192 0 FLAG -320 -64 gene_1 IOPIN -320 -64 Out FLAG -480 144 0 FLAG -96 48 V+ IOPIN -96 48 BiDir FLAG -96 112 V- IOPIN -96 112 BiDir FLAG -16 -64 Protein_1 IOPIN -16 -64 Out FLAG 208 80 V+ IOPIN 208 80 BiDir FLAG 208 144 V- IOPIN 208 144 BiDir FLAG 416 208 0 FLAG 288 -48 gene_2 IOPIN 288 -48 Out FLAG 128 160 0 FLAG 512 64 V+ IOPIN 512 64 BiDir FLAG 512 128 V- IOPIN 512 128 BiDir FLAG 592 -48 Protein_2 IOPIN 592 -48 Out FLAG 784 80 V+ IOPIN 784 80 BiDir FLAG 784 144 V- IOPIN 784 144 BiDir FLAG 992 208 0 FLAG 864 -48 gene_3 IOPIN 864 -48 Out FLAG 704 160 0 FLAG 1088 64 V+ IOPIN 1088 64 BiDir FLAG 1088 128 V- IOPIN 1088 128 BiDir FLAG 1168 -48 Protein_3 IOPIN 1168 -48 Out SYMBOL Misc\\battery 128 -240 R270 WINDOW 0 32 56 VTop 0 WINDOW 3 -32 56 VBottom 0 WINDOW 123 0 0 Left 0 WINDOW 39 0 0 Left 0 SYMATTR InstName V1 SYMATTR Value 12 SYMBOL Misc\\battery 448 -240 R90 WINDOW 0 -32 56 VBottom 0 WINDOW 3 32 56 VTop 0 WINDOW 123 0 0 Left 0 WINDOW 39 0 0 Left 0 SYMATTR InstName V2 SYMATTR Value 2 SYMBOL res -464 64 R90 WINDOW 0 0 56 VBottom 0 WINDOW 3 32 56 VTop 0 SYMATTR InstName R1 SYMATTR Value 1k SYMBOL res -336 -48 R90 WINDOW 0 0 56 VBottom 0 WINDOW 3 -54 55 VTop 0 SYMATTR InstName R2 SYMATTR Value 10k SYMBOL Opamps\\UniversalOpamp2 -400 96 R0 SYMATTR InstName U2 SYMBOL res -208 80 R90 WINDOW 0 64 52 VBottom 0 WINDOW 3 -26 58 VTop 0 SYMATTR InstName R3 SYMATTR Value 100k SYMBOL Opamps\\UniversalOpamp2 -96 80 R0 SYMATTR InstName U1 SYMBOL cap -208 128 R0 SYMATTR InstName C1 SYMATTR Value 10µf SYMBOL res 144 80 R90 WINDOW 0 0 56 VBottom 0 WINDOW 3 32 56 VTop 0 SYMATTR InstName R4 SYMATTR Value 1k SYMBOL res 272 -32 R90 WINDOW 0 0 56 VBottom 0 WINDOW 3 -54 55 VTop 0 SYMATTR InstName R5 SYMATTR Value 10k SYMBOL Opamps\\UniversalOpamp2 208 112 R0 SYMATTR InstName U3 SYMBOL res 400 96 R90 WINDOW 0 64 52 VBottom 0 WINDOW 3 -26 58 VTop 0 SYMATTR InstName R6 SYMATTR Value 100k SYMBOL Opamps\\UniversalOpamp2 512 96 R0 SYMATTR InstName U4 SYMBOL cap 400 144 R0 SYMATTR InstName C2 SYMATTR Value 10µf SYMBOL res 720 80 R90 WINDOW 0 0 56 VBottom 0 WINDOW 3 32 56 VTop 0 SYMATTR InstName R7 SYMATTR Value 1k SYMBOL res 848 -32 R90 WINDOW 0 0 56 VBottom 0 WINDOW 3 -54 55 VTop 0 SYMATTR InstName R8 SYMATTR Value 10k SYMBOL Opamps\\UniversalOpamp2 784 112 R0 SYMATTR InstName U5 SYMBOL res 976 96 R90 WINDOW 0 64 52 VBottom 0 WINDOW 3 -26 58 VTop 0 SYMATTR InstName R9 SYMATTR Value 100k SYMBOL Opamps\\UniversalOpamp2 1088 96 R0 SYMATTR InstName U6 SYMBOL cap 976 144 R0 SYMATTR InstName C3 SYMATTR Value 10µf SYMBOL res -464 -48 R90 WINDOW 0 0 56 VBottom 0 WINDOW 3 32 56 VTop 0 SYMATTR InstName R10 SYMATTR Value 10k SYMBOL noise_module -624 -32 R0 SYMATTR InstName X1 SYMBOL constant_module -800 -64 R0 WINDOW 39 -67 -24 Left 0 SYMATTR InstName X2 SYMATTR SpiceLine constant=1e-5 SYMBOL constant_module -800 -16 R0 WINDOW 39 -74 52 Left 0 SYMATTR InstName X3 SYMATTR SpiceLine constant = 1e5 TEXT 696 -232 Left 0 !.tran 0 20 0 0.001 TEXT 200 -360 Left 0 ;Repressilator TEXT -880 -240 Left 0 ;Noise source simulates resistor noise of Vn(RMS)= sqrt(4*KB*T*R*(bandwidth)) TEXT 88 -160 Left 0 ;Gene expression and protein production unit RECTANGLE Normal 608 240 48 -176 1